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Amniotic Allograft (Stem Cells)

Allograft: a tissue graft from a donor of the same species as the recipient.  It is used in the healing process.  

What is Amniotic Allograft? 

Amniotic allograft is tissue derived from human amniotic membrane and fluid. Placental tissue is donated by healthy mothers at the time of delivery at a scheduled cesarean section.  The placenta is very rich in components that have strong healing properties when injected into another person. We use PalinGenR which are allografts filled with collagen, hyaluronic acid, mesenchymal stem cells, growth factors, cytokines, fibrinogen and messenger RNA.  These specialized cells are used by your body to decrease inflammation, rebuild tissue and become the cells that your body needs to repair1.  This can be following an injury, degenerative process or even after surgery.  This is one of the tools used in Regenerative Medicine.

Where does the Allograft come from?

The material we use in our clinic, the amniotic allograft, is donated by a pregnant woman.   The placenta is taken during a C-section after her baby is born.  This material is recovered with the mother's consent following a live birth. 

A rigorous screening process occurs before any placental tissue is harvested.  Donors are healthy women between the ages of 18-45 years.  Prior to the delivery a thorough medical and social history is collected to ensure the mother meets the high standards of eligibility.  Donors are thoroughly screened for communicable diseases.  Ultimately, approval of the tissue for use is made by the Medical Director, following an intensive and complete medical review and pre-natal evaluation prior to delivery.  

Once the baby is delivered via C-section, the placenta and fluid, which has been discarded in the past, is now saved.  These tissues are then extensively tested for viability and safety.

This process is performed at several facilities around the USA.  They follow very strict guidelines with stringent screening and recovery protocols.  This is done in a highly controlled environment.         

What conditions are typically treated with Amniotic Allograft / Regenerative Medicine?

  • Osteoarthritis
  • Bursitis
  • Tendonitis
  • Cartilage tears
  • Rotator cuff tears
  • Ligament or tendon tears 

How long have amniotic tissue based products been used?

Although the popularity in orthopedics and pain management is relatively new, amniotic derived products have a 100 year history of being used in other disciplines for their healing properties.2 

What can I expect if I wish to proceed with this option?

You will first meet with our health professionals.  A thorough examination and x-rays will be obtained of the area(s) of complaint.  Outside imaging may be reviewed, such as an MRI.  If you are found to be a candidate for the procedure our professionals will guide you through the process.  

The allograft (stem cells) is ordered and it is flown overnight under strict temperature and packaging guidelines.  Our experienced Nurse Practitioner injects a tailored dose of amniotic allograft serum (stem cells) using state of the art ultrasound guided technology.  As soon as you are injected with the amniotic allograft serum, regeneration begins as cell growth is triggered.  This process will continue for months.  The cells grow and divide, creating new tissues in the injured area. 

The injection process is done in our injection suite during one visit and there is no down time.  You will have minor limitations for 2 weeks to allow the material to stay in the area that was injected so it can work through the healing process.  There are times when we may use a brace to support the affected joint. This is done on a case by case basis. Rehabilitation may also be a part of your care plan.  Rehab is done in our large rehab facility on site and at home.

How is this procedure different from other clinics?

Some clinics use your own tissue from the hip or adipose (fat) layer.  While this may sound appealing it is generally less effective.  It also requires more injections as the harvest process is also needed.  There are no cells more fresh and new than those found in a placenta.  As we age, so do our cells.  This is not the ideal source of material as the viability and the ability to differentiate decline the older we get.  

There are also companies that use the entire placenta.  This means that the cells on the mother's side of the placenta (chorion layer) have to be treated as they have been known to cause an antigen (allergic) response.  This further degrades the cells that are ultimately injected into the injured person. 

PalinGenR only uses the baby’s side of the placenta (amnion layer) for injection which allows the material to be more viable and readily available to help the injured person.   At Wisconsin Center for Integrative Health, we feel this is the most effective treatment for our patients.  

Is there any chance of rejection?

The product being injected will become integrated into the site of injection with no immune system rejection. 


Case #1 Knee

When my orthopedic surgeon told me I needed a knee replacement because my knee was almost bone-on-bone, I started to inquire about a stem cell injection procedure.  When my Chiropractor indicated he was going to provide that service very soon (through a Nurse Practitioner at their clinic), I decided I would have that procedure.

I made the appointment and had the injection.  By the next day my leg was stronger and the best part, my pain was basically gone.  It was amazing to me that even though the cartilage had not had a chance to grow back yet, the pain was gone and my leg seemed almost back to normal.  Best of all, I still have my own knee!

I would recommend patients inquire about this procedure before having a complete knee replacement.

-80 year old female

Case #2 Hip

I would like to share with you the experience I had with Tenold Chiropractic.  Believe me when I say on am not much on writing reviews on any products or services that are not above my expectations.  

In June of 2017 I had a back spasm that brought me down to my knees.  I had a tough time even trying to stand up.  After one particularly painful night of this my wife took me to the emergency room.  They took x-rays and after a 4.5 hour visit I was released with one bottle of heavy duty pain killers and one bottle of muscle relaxers.  I spent the next four days in bed.  

I decided to call Tenold Chiropractic and I was told to come right in. I met with Dr. Scott Tenold.  After a thorough exam and more x-rays he determined I had two bulged discs in my lower back.  After one short week he had me walking upright again and on the road to recovery.  He also discovered the root cause of my constant back pain: my right hip was locked up, with no range of motion which was working against  the muscles in my back.  All this time I thought it was my back causing my hip problem along with getting older.  He then informed me that they would be expanding their services and would be doing stem cell injections.  He noted that I would be a good candidate for this procedure.  With the controversy I have seen and read about, this was kind of scary to me.  My alternative would be a hip replacement in a couple of years.  I had a lot of questions that had to be answered (being of the Christian faith) where did the cells come from?  How is the procedure done and by whom?  What was the success rate of the procedure done at other clinics?  These are just a few of the questions that I asked, and Dr. Scott filled me on some that I did not ask.  Dr. Scott and his staff did their research and training.  This was a leaning trend for me and I had to feel comfortable with the outcome and the cost which was not covered by insurance.  

At the time of this letter it has been 19 days since my stem cell injection.  I am totally blown away!  Prior to the stem cell injection, I could only cross my right foot over my left foot at the ankle.  Now I can actually cross my right leg on my left knee, put my sock and shoe on my right foot without pulling the muscle across my back and feeling the sharp pain that followed.  They say it can continue to improve over the next 12 months yet I am amazed after 19 days.  I cannot wait to see the results over the next few months!  

My sincere thanks to Dr. Scott, Dr. Lisa, Jen (Nurse Practitioner) and other members of their staff that were involved in my treatment. They were professional, knowledgeable and well trained in my care and in the procedure.  I would also like to thank them for saying a prayer with me prior to the procedure as that meant a lot to me.  

-WMK, 64 year old male

Related Links:

1. Complements and the Wound Healing Cascade: An Updated Review. Hani Sinno and Satya Prakash. Plast Surg Int. 2013: 2013: 146764

2. The Grafting of Preserved Amniotic Membrane to Burned and Ulcerated Surfaces, Substituting Skin Grafts: A Preliminary Report. Maximilian Stern. JAMA. 1913;60(13):973-974

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